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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

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Tests on humans include a pilot study, which recruited 2 participants who received BPC-157 intravenously, and a Phase I human trial, which involved 47 participants, but for which the results were not published

These localized reactions typically resolve quickly